Catalytic synthesis of enantiopure mixed diacylglycerols – synthesis of a major M. tuberculosis phospholipid and platelet activating factor.
نویسندگان
چکیده
An efficient catalytic one-pot synthesis of TBDMS-protected diacylglycerols has been developed, starting from enantiopure glycidol. Subsequent migration-free deprotection leads to stereo- and regiochemically pure diacylglycerols. This novel strategy has been applied to the synthesis of a major Mycobacterium tuberculosis phospholipid, its desmethyl analogue, and platelet activating factor.
منابع مشابه
P 143: The Effect of Platelet Activating Factor on Inflammatory Response in Multiple Sclerosis
Multiple sclerosis is an autoimmune disease of the central nervous system which its main characteristic is an inflammation and demyelination and subsequent, neural degeneration. Many studies have shown that inflammation causing neuronal demyelination. MS is the most common cause of chronic neurological disability in during youth which the prognosis is that can be death. Platelet activating fact...
متن کاملNano composite mixed-addenda vanadium substituted polyoxometalate-TiO2 as a green, reusable and efficient catalyst for rapid and efficient synthesis of symmetric disulfides under ultrasound irradiation
Mixed-addenda vanadium substituted polyoxometalate supported on anatase TiO2 crushed nano leaf was synthesized by an unusual reaction with titanium tetraisopropoxide at 100 ºC via sol–gel method under oil-bath condition. The materials characterized by XRD, TEM, IR and UV–vis techniques. In the present work, efficient oxidative of thiols with polyoxometalate-TiO2/hydrogen peroxide ...
متن کاملEffect of Different Fatty Acids on Glycerolipid Synthesis in Isolated Rat Henatocvtes*
Glycerolipid synthesis from [3H]glycerol and [l*C]dihydroxyacetone operated in enqmically isolated rat hepatocytes at a rate similar to that in the intact organ. Addition of albumin-bound fatty acids with more than 12 carbon atoms to the incubation medium markedly stimulated triacylglycerol synthesis from [3H]glycerol whereas the effects on phospholipid synthesis were smaller and more dependent...
متن کاملPreparation of H-ZSM-5 Nano-Zeolite Using Mixed Template Method and its Activity Evaluation for ethanol to DME Reaction
H-ZSM-5 nano-zeolites were synthesized by hydrothermal method using tetrapropylammonium hydroxide (TPAOH) as a template in the presence of various TPABr concentrations. The effect of different TPABr/TPAOH molar ratios was studied on the catalytic performance of dehydration of methanol to dimethyl ether (DME) in a fixed bed reactor under the same operating conditions (T=300°C, P=1 atm, and WHSV=...
متن کاملEffect of Different Fatty Acids on Glycerolipid Synthesis in Isolated Rat Henatocvtes*
Glycerolipid synthesis from [3H]glycerol and [l*C]dihydroxyacetone operated in enqmically isolated rat hepatocytes at a rate similar to that in the intact organ. Addition of albumin-bound fatty acids with more than 12 carbon atoms to the incubation medium markedly stimulated triacylglycerol synthesis from [3H]glycerol whereas the effects on phospholipid synthesis were smaller and more dependent...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 11 40 شماره
صفحات -
تاریخ انتشار 2013